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Aim To investigate the hypoglycemic pathway of terpenes from Cornus officinalis(TCF) from three aspects of insulin dependence, α-glucosidase inhibition, insulin sensitizing.Methods Insulin-deficient diabetes mellitus(DM) model was induced by tail vein injection of streptozotocin(STZ) into SD rats at the dose of 50mg·kg-1 body weight.Rats were randomly divided into seven groups: control group(CON), model group(Model), metformin group(Met) 0.1g·kg-1, shenqi jiangtang granules(Shenqi) group 1.0 g·kg-1, three dose groups of TCF: 0.10, 0.05, 0.025 g·kg-1.Body weight and blood glucose were measured every week.After four weeks, glycosylated hemoglobin (HbA1c), glycosylated serum protein (GSP) were determined.Normal ICR mice were divided into seven groups: CON, Model, Met group 0.2g·kg-1, acarbose group(Acar) 0.1 g·kg-1, Shenqi group 1.5g·kg-1, three dose groups of TCF: 0.20g·kg-1;0.10g·kg-1;0.05 g·kg-1.After 10 days of administration, intraperitoneal injections of glucose and gavage starch tolerance tests were employed.Normal SD rats were divided into six groups: CON, rosiglitazone group 0.02 g·kg-1, glipizide group 0.02 g·kg-1, three dose groups of TCF: 0.10, 0.05, 0.025 g·kg-1.After seven days of administration, intraperitoneal glucose tolerance test(IPGTT) was employed and levels of insulin was determined.Results (1)High dose of TCF significantly reduced the level of HbA1c(P<0.05), GSP(P<0.05) on STZ model rats;(2)TCF significantly improved the glucose tolerance and gavage starch tolerance in ICR mice(P<0.05);(3) High dose of TCF significantly reduced the blood glucose and serum insulin level.Conclusions TCF has obvious effects on inhibiting glucose absorb and promoting the use of glucose.It is able to exert hypoglycemic effect through non-insulin dependent pathway, whereas, whether it has the effects of α-glucosidase inhibition and insulin sensitization should be further validated.
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Objective: The configuration of fixed assets in hospital, should meet the need of diagnosis, treatment and daily operation. Methods: By considering the input, output and evaluation of fixed assets in the management process, which related to the medium and long term development, we find a way to establish the information platform of fixed assets, which actually conforms to the hospital operation. Results:Effectively, the management of fixed assets was lead to a virtuous cycle. Conclusion: In the management process, economic benefits management, performance and quality management and evaluation should be different among different kinds of fixed assets. Thus, the hospital managers should focus and treat them differently, in order to achieve better or more effective management.
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This paper analyzed the present status of the statistical teaching in medical sciences university and indicated that statistical teaching plays an important role in improving the students' Scientific Research Practice Ability.
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Objective To investigate the preoperative design and application of the minimum foveolar translocation distance and angle of macular translocation. Methods The fundus fluorescein and indocyanine green angiographies were performed on 53 eyes of 53 patients with classic subfoveal choroidal neovascularization (SCNV), including 42 with exudative age-related macular degeneration and 11 with high myopic macular degeneration. The actual area of macular SCNV and the minimum foveolar translocation distance and angle were analyzed. Results The actual area of SCNV was 0.39~18.00 mm 2 with the mean of (3.08?3.22) mm 2. The designed minimum superior translocation distance was 67~2 240 ?m with the mean of (845.72?425.23) ?m;the minimum designed minimum inferior translocation distance was 53~ 2 430 ?m with the mean of (912.17?547.77) ?m. The minimum designed superior translocation angle was 1~32? with the mean of (13.23?6.68)?;the minimum designed inferior translocation angle was 1~35? with the mean of (14.06?8.46)?. The individual difference of the minimum designed superior and inferior translocation distance was more than 500 ?m in 16 eyes (30.19%), and the difference of translocation angle was more than 10? in 11(20.75%). Conclusion Preoperative design of minimum translocation distance and angle of macular translocation may be helpful to choose the operation program.
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Objective To observe the characteristics of indocyanine green angiography and fundus fluorescein angiography (ICGA& FFA) in anterior ischemic optic neuropathy ( AION ) , and to investigate the etiology of AION and the value of ICGA and FFA in the diagnosis and study of AION. Methods Simultaneous ICGA and FFA were performed on 32 eyes of 31 AION patients and 38 eyes of 38 non AION patients. Results The eyes that all or a part of the optic disc lies in the watershed zones of the choroidal blood supply were significantly more in the AION group than those in the non AION group (P
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This paper presents the application of Cox regression model in survival analysis of lung cancer for the first time in China.By using Cox model,a multivariate analysis was made on 191 patients with lung cancer treated by operation. Among the twenty three factors, only pathological sort, the size of tumor,lymph node metastases,type of operai ions, infiltra -ing across the end of tumor,and complications showed a high significance with prognostic relationship. Of those factors influecing postoperative survivaltime,lymph node metastases, is detrimental for patients, squamasum carcinoma and lobectomy are preferable. From survival curves of groups of different harzad groups,fit in the model and survival rale in the interclass was calculated, Therefore it showed advantages using Cox regression model in multivariate survival analysis